Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Supersensitivity psychosis with concurrent episodic vomiting.

K Malcolm1

  • 1University Department of Psychiatry, Northern General Hospital, Sheffield.

The British Journal of Psychiatry : the Journal of Mental Science
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vitro and clinical evaluation of OATP-mediated drug interaction potential of sacubitril/valsartan (LCZ696).

Journal of clinical pharmacy and therapeutics·2016
Same author

Antidepressant drug treatment in relation to the use of ECT.

Journal of psychopharmacology (Oxford, England)·2012
Same author

An integrated genomic approach identifies ARID1A as a candidate tumor-suppressor gene in breast cancer.

Oncogene·2011
Same author

Multiple conformational epitopes are recognized by natural and induced immunity to the E7 protein of human papilloma virus type 16 in man.

Intervirology·2000
Same author

Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins.

Vaccine·2000
Same author

HPV6b virus like particles are potent immunogens without adjuvant in man.

Vaccine·1999
Same journal

Effectiveness and safety of repeat dose subcutaneous ketamine for treatment-resistant depression, and the impact of prior ketamine treatment: open label extension of the KADS study.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Definitional invisibility: when institutional language reframes identity as choice.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Potential implications of removing evidence of impairment from the DSM-5 age-of-onset criterion in adult ADHD assessment.

The British journal of psychiatry : the journal of mental science·2026
Same journal

The pressurised leaky funnel: rethinking recruitment, selection and retention in the UK psychiatry workforce.

The British journal of psychiatry : the journal of mental science·2026
Same journal

Cutting through stigma: psychiatry and neurosurgery working together.

The British journal of psychiatry : the journal of mental science·2026
Same journal

A fourth pillar for evidence-based medicine: implications for psychiatry - CORRIGENDUM.

The British journal of psychiatry : the journal of mental science·2026
See all related articles

This case study highlights a patient with long-term psychiatric illness experiencing severe symptoms like hallucinations and self-neglect. Increased neuroleptic medication successfully managed vomiting, suggesting dopaminergic supersensitivity.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Long-term psychiatric conditions often require chronic neuroleptic treatment.
  • Neuroleptic medications target dopamine pathways to manage psychiatric symptoms.
  • Dopaminergic supersensitivity is a potential complication of long-term antipsychotic use.

Observation:

  • A patient with a 15-year psychiatric history on neuroleptics presented with vomiting, thought alienation, auditory hallucinations, and self-neglect.
  • The patient's symptoms suggested a complex interplay between their underlying psychiatric condition and medication effects.
  • Vomiting, in this context, was an unusual but significant presenting symptom.

Findings:

  • Dopaminergic supersensitivity was diagnosed as the underlying cause of the patient's symptoms.

Related Experiment Videos

  • Increasing the dose of neuroleptic medication led to the cessation of vomiting.
  • This suggests a paradoxical effect where higher dopamine blockade ameliorated a symptom potentially linked to dopamine dysregulation.

    • Implications:

    • This case underscores the importance of considering dopaminergic supersensitivity in patients with treatment-resistant or unusual symptoms.
    • Adjusting neuroleptic dosages, even increasing them, can be a viable strategy for managing specific adverse effects.
    • Further research into the mechanisms of dopaminergic supersensitivity and its management is warranted.