Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Active cell death in hormone-dependent tissues.

M P Tenniswood1, R S Guenette, J Lakins

  • 1Department of Biochemistry, Faculty of Medicine, University of Ottawa, Ontario, Canada.

Cancer Metastasis Reviews
|September 1, 1992
PubMed
Summary

Hormone ablation induces active cell death (ACD) in hormone-dependent tissues like the prostate. Differential sensitivity of epithelial cells to ACD is influenced by stromal interactions, impacting hormone resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recommendations for Integrating Caries Risk Assessment into Primary Care for Indigenous Children.

JDR clinical and translational research·2025
Same author

A phase I study of the CSF1R inhibitor vimseltinib in combination with the PD-L1 inhibitor avelumab in patients with advanced sarcoma.

ESMO open·2025
Same author

Indications for primary aldosteronism screening in people with hypertension and hyperparathyroidism: a multi-centre cohort study.

Endocrine·2025
Same author

Epidemiology, Treatment Patterns and Survival in Canadian Patients With Chronic Hepatitis B-Related Hepatocellular Carcinoma.

Journal of viral hepatitis·2024
Same author

Improving workplace mental health literacy in Hong Kong: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, Toronto, Ont., September 6-9, 2007.

Canadian journal of surgery. Journal canadien de chirurgie·2023

Area of Science:

  • Cell Biology
  • Endocrinology
  • Oncology

Background:

  • Hormone-dependent tissues (prostate, mammary gland) undergo active cell death (ACD) upon hormonal manipulation.
  • ACD can be induced by hormone ablation, anti-hormones, calcium channel agonists, and TGF-beta.
  • Specific genes like TRPM-2, transglutaminase, PARP, and Hsp27 are upregulated during ACD.

Purpose of the Study:

  • To review the underlying biology of active cell death in prostate and mammary glands.
  • To discuss the relevance of ACD in the context of hormone resistance.
  • To explore the differential sensitivity of epithelial cells to ACD induction.

Main Methods:

  • Review of existing literature on active cell death in hormone-dependent tissues.
  • Analysis of gene expression changes associated with ACD.

Related Experiment Videos

  • Examination of cellular localization and stromal interactions in sensitive and resistant cell populations.

    • Main Results:

    • Hormone ablation and specific agents readily induce ACD in hormone-dependent epithelial cells.
    • Differential sensitivity to ACD exists among epithelial cells, influenced by location and stromal contact.
    • Prostatic secretory cells in distal ducts are sensitive; proximal cells are more resistant due to basal cell-stroma interaction.

    Conclusions:

    • Stromal interactions play a critical role in modulating epithelial cell sensitivity to ACD.
    • Understanding ACD mechanisms is crucial for addressing hormone resistance in prostate and mammary gland cancers.
    • Further research into unidentified ACD-related genes may reveal new therapeutic targets.