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Related Experiment Videos

Cutaneous myelofibrosis.

D M Hoss1, N S McNutt

  • 1Department of Pathology, New York Hospital-Cornell University Medical Center, New York.

Journal of Cutaneous Pathology
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Cutaneous extramedullary hematopoiesis is rare in adults, typically linked to myelofibrosis. This case highlights atypical skin nodules in a 65-year-old woman, presenting diagnostic challenges.

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Area of Science:

  • Hematology
  • Dermatopathology
  • Oncology

Background:

  • Cutaneous extramedullary hematopoiesis (CEH) is a rare condition, predominantly seen in neonates.
  • In adults, CEH is exceptionally rare, with only 20 reported cases, all associated with myelofibrosis.
  • Distinguishing CEH infiltrates from other skin conditions like leukemia cutis can be challenging.

Observation:

  • A 65-year-old woman with myelofibrosis developed approximately 40 violaceous, firm, non-tender cutaneous nodules.
  • The nodules, measuring 1-4 cm, were located on the abdomen near a splenectomy scar.
  • Skin lesions remained grossly unchanged for one year.

Findings:

  • Histopathology revealed dense myeloid cell infiltrates and atypical megakaryocyte-like cells.

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  • Increased reticulin was noted, particularly around atypical megakaryocytes.
  • Immunohistochemistry confirmed myeloid cells (MAC 387) and atypical megakaryocytes (Factor XIIIa, Factor VIII-related antigen).

    • Implications:

    • This case expands the understanding of rare adult CEH presentations.
    • Highlights the importance of histopathological and immunohistochemical analysis for accurate diagnosis.
    • Emphasizes the need to consider CEH in adults with myelofibrosis presenting with unusual skin lesions.