Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integration and control of circulatory function.

A C Guyton, A W Cowley, D B Young

    International Review of Physiology
    |January 1, 1976
    PubMed
    Summary

    Intrinsic circulatory control mechanisms ensure stable blood flow and fluid balance. While nervous and hormonal systems play roles, intrinsic controls are crucial for long-term regulation, despite past underemphasis due to complexity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    HEMODYNAMICS.

    A listing of research in the cardiovascular field·2014
    Same author

    Electronic counting and size determination of particles in aerosols.

    The Journal of industrial hygiene and toxicology·2010
    Same author

    Physiology of botulinus toxin.

    Archives of neurology and psychiatry·2010
    Same author

    Measurement of the respiratory volumes of laboratory animals.

    The American journal of physiology·2010
    Same author

    Analysis of respiratory patterns in laboratory animals.

    The American journal of physiology·2010
    Same author

    A verstile square wave nerve stimulator.

    The Review of scientific instruments·2010

    Area of Science:

    • Physiology
    • Cardiovascular System
    • Homeostasis

    Background:

    • The regulation of circulation involves intrinsic, nervous, and hormonal control systems.
    • Intrinsic mechanisms, including autoregulation and fluid distribution, are vital for stable long-term circulatory control.
    • Previous emphasis may have overestimated the role of nervous and hormonal controls while underestimating intrinsic complexities.

    Purpose of the Study:

    • To highlight the significance of intrinsic circulatory control mechanisms.
    • To re-evaluate the relative importance of intrinsic versus extrinsic (nervous and hormonal) regulatory systems.
    • To discuss the complexities and challenges in understanding intrinsic circulatory controls.

    Main Methods:

    • Review of experimental findings on intrinsic circulatory control.
    • Analysis of the roles of nervous and hormonal systems in circulatory regulation.
    • Discussion of specific intrinsic mechanisms like autoregulation, cardiac output control, and fluid balance.

    Main Results:

    • Intrinsic mechanisms provide stable long-term control of circulation and blood pressure.
    • Nervous controls are essential for acute arterial pressure regulation and drives for water intake.
    • Hormonal systems, like renin-angiotensin, play roles in blood pressure and fluid balance, with thirst/ADH critical for sodium and aldosterone for potassium homeostasis.

    Conclusions:

    • Intrinsic mechanisms are fundamental for stable, long-term circulatory regulation.
    • Nervous and hormonal systems are important but their roles, particularly in long-term blood volume control by ADH and aldosterone, may have been overemphasized.
    • Understanding the complexities of intrinsic controls is key to appreciating their full contribution to cardiovascular homeostasis.

    Related Experiment Videos