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The emergence of the chaperone machines
1Département de Biochimie Médicale, Centre Médical Universitaire, Geneve, Switzerland.
Trends in Biochemical Sciences
|August 1, 1992
Abstract:
To ensure proper polypeptide folding, oligomerization and transport, elaborate molecular 'chaperone machines' have evolved. These machines are usually composed of a major chaperone protein that binds promiscuously to nascent, unfolded, misfolded or aggregated polypeptides and a set of chaperone 'cohorts', whose function is to enhance efficiency and ensure recycling. These chaperone machines can function by themselves or synergistically to carry out their various tasks.