[The pathogenesis of the renal syndrome in hemorrhagic fever]

Lipid peroxidation was investigated in 89 patients suffering from hemorrhagic fever with renal syndrome. In addition to routine tests, measurements were made of plasma malonic dialdehyde and acyl hydroperoxides the levels of which were found increased 1.3-1.4-fold and 1.5-2-fold, respectively, in the severe disease compared to control values. The degree of lipid peroxidation intensification and aggravation of the symptoms proved to agree. It is suggested that abnormal lipid peroxidation contributes to development of renal syndrome which in hemorrhagic fever may progress to acute renal failure.