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Interleukin-6 in normal skin and psoriasis
A Castells-Rodellas1, J V Castell, A Ramirez-Bosca
1Service of Dermatology, Hospital General Vall D'Hebron, Barcelona, Spain.
Acta Dermato-Venereologica
|January 1, 1992
Summary
Interleukin-6 (IL-6) is present in normal skin cells. In psoriasis, IL-6 is highly detected in skin cells, suggesting it contributes to abnormal skin cell growth.
Area of Science:
- Dermatology
- Immunology
- Cell Biology
Background:
- Interleukin-6 (IL-6) is a cytokine found in normal human skin.
- It is detected in various skin cells including keratinocytes, endothelial cells, and fibroblasts.
Purpose of the Study:
- To investigate the presence and role of IL-6 in normal human skin and psoriatic lesions.
- To explore the potential contribution of IL-6 to the hyper-proliferation of keratinocytes in psoriasis.
Main Methods:
- Immunological detection of IL-6 in normal and psoriatic skin samples.
- Analysis of IL-6 localization within different skin cell types and appendages.
Main Results:
- IL-6 was identified in basal keratinocytes, endothelial cells, fibroblasts, and sudoriparous ducts in normal skin.
- Intense IL-6 labeling was observed in all epidermal layers and skin appendages in psoriatic lesions.
- IL-6 acts synergistically with Interleukin-1 (IL-1) and Tumour Necrosis Factor (TNF).
Conclusions:
- IL-6 is a component of normal human skin with a significant presence in psoriatic lesions.
- IL-6 may play a role in modulating epidermal hyper-proliferation in psoriasis through its receptor action, potentially interacting with Epidermal Growth Factor (EGF) pathways.