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Abnormalities of lymphocyte function and phenotypic pattern in a case of toxic epidermal necrolysis
H Hagdrup1, E Tønnesen, O Clemmensen
1Department of Dermatology, Odense University Hospital, Denmark.
Acta Dermato-Venereologica
|August 1, 1992
Abstract:
We examined the blood lymphocyte function and phenotypic pattern in a patient with toxic epidermal necrolysis after taking salazopyrin. We studied cell surface markers, natural killer cell activity and mitogen-induced lymphocyte transformation. Our results point to temporary immunosuppression as evidenced by lymphopenia with a large "null cell" population, reduced natural killer cell activity, and impaired lymphocyte response to mitogens.