Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vecuronium: an anthropometric comparison.

I T Houghton1, C S Aun, T E Oh

  • 1British Military Hospital, Hong Kong.

Anaesthesia
|September 1, 1992
PubMed
Summary

Nepalese patients in Nepal showed reduced response to vecuronium, a neuromuscular blocker, compared to other groups. Differences in body measurements may explain this varying response to the drug.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mismatched connections.

Anaesthesia and intensive care·2008
Same author

Calculating the volume of the oxygen reservoir bag for the Triservice anaesthetic apparatus.

Anaesthesia·2008
Same author

The Fluotec--early advertising.

Anaesthesia and intensive care·2007
Same author

Configuration of draw-over anaesthetic breathing system.

Anaesthesia·2007
Same author

A reservoir bag for the Triservice anaesthetic apparatus.

Anaesthesia·2006
Same author

Some observations on early military anaesthesia.

Anaesthesia and intensive care·2006

Area of Science:

  • Pharmacology and Anesthesiology
  • Clinical Medicine
  • Anthropology

Background:

  • Vecuronium is a neuromuscular blocking agent commonly used in anesthesia.
  • Patient factors, including ethnicity and sex, can influence drug response.
  • Previous studies suggest potential variations in vecuronium sensitivity across different populations.

Purpose of the Study:

  • To investigate potential resistance to vecuronium in Nepalese patients in Nepal.
  • To compare vecuronium response in Nepalese patients in Nepal with Nepalese, Chinese, and European patients in Hong Kong.
  • To explore the influence of anthropometric differences and sex on vecuronium efficacy.

Main Methods:

  • A comparative study involving four groups of patients (Nepalese in Nepal, Nepalese in Hong Kong, Chinese in Hong Kong, European in Hong Kong).
  • Each group consisted of 10 male and 10 female patients.
  • Patients received 0.1 mg.kg-1 of vecuronium, followed by intubation after 60 seconds; intubating conditions and anthropometric measurements were assessed.

Main Results:

  • Nepalese patients in Nepal exhibited significantly less satisfactory intubating conditions compared to other groups (p = 0.002).
  • Male patients, across all groups, showed significantly poorer intubating conditions than female patients (p = 0.004).
  • Significant differences in anthropometric measurements were observed between patients in Nepal and Hong Kong, as well as between sexes.

Conclusions:

  • The study suggests a potential difference in vecuronium response among Nepalese patients in Nepal.
  • Observed variations in intubating conditions may be linked to anthropometric differences, including body composition and distribution volume.
  • Further research is warranted to elucidate the precise mechanisms underlying these population-specific responses to vecuronium.

Related Experiment Videos