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Biochemical variables associated with bone density in patients with primary hyperparathyroidism
A Bergenfelz1, B Lindergård, B Ahrén
1Department of Surgery, Lund University, Sweden.
The European Journal of Surgery = Acta Chirurgica
|September 1, 1992
Summary
Primary hyperparathyroidism shows little association with bone density. Serum osteocalcin and 1,25 dihydroxycholecalciferol levels correlated with bone density, not parathyroid hormone levels.
Area of Science:
- Endocrinology
- Bone Metabolism
- Mineral Metabolism
Background:
- Primary hyperparathyroidism (PHP) is a common endocrine disorder.
- Cortical osteopenia is a significant complication, but its association with PHP is not fully understood.
Purpose of the Study:
- To investigate the relationship between primary hyperparathyroidism and cortical bone density.
- To identify biochemical markers associated with bone loss in PHP.
Main Methods:
- An open study involving 38 patients with primary hyperparathyroidism.
- Bone density was measured using single photon absorption.
- Correlations were assessed between bone density and various biochemical markers, including parathyroid hormone, ionized calcium, osteocalcin, and vitamin D metabolites.
Main Results:
- No significant correlation was found between bone density and serum parathyroid hormone, ionized calcium, or age.
- Serum concentrations of 1,25 dihydroxycholecalciferol and osteocalcin showed a significant positive correlation with bone density (p < 0.05).
- Serum osteocalcin demonstrated the strongest correlation with bone density among all biochemical variables.
Conclusions:
- Bone density in primary hyperparathyroidism is weakly associated with serum parathyroid hormone levels.
- Osteocalcin and 1,25 dihydroxycholecalciferol are potential indicators of bone health in patients with PHP.