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Updated: Aug 18, 2026
Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
Published on: May 22, 2012
Characterization of seven kidney tumors by flow cytometry: analysis of cell cycle, DNA content and P-glycoprotein
G Lizard1, P Roignot, L Dusserre-Guion
1Centre Commun de Cytofluorométrie, INSERM U80, Hôpital Edouard-Herriot, Lyon, France.
Abstract:
Seven kidney tumors obtained from patients aged from 5 to 76 years were analyzed by flow cytometry for cell cycle, DNA content and P-glycoprotein expression involved in multidrug resistance. The DNA index seems to be an important criterion since all the tumors were aneuploid. In a case of clear cell carcinoma, two aneuploid clones were identified. In 5 cases of kidney tumors a high proportion of cells in proliferation (S + (G2 + M)) was observed; it was comprised between 13 and 33%. As for P-glycoprotein it was detected only in few tumor cells (5-15%) respectively in a case of clear cell carcinoma and in a case of Wilms' tumor.
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