Related Experiment Videos
Metabotropic receptor mediated afterdepolarization in neocortical neurons
C Greene1, P Schwindt, W Crill
1Department of Physiology and Biophysics, University of Washington, Seattle 98195.
European Journal of Pharmacology
|July 1, 1992
Abstract:
In rat neocortical slices activation of glutamate metabotropic receptors with glutamate, quisqualate and 1S,3R-ACPD caused a spike-evoked afterdepolarization which replaced the normal afterhyperpolarization. In some neocortical neurons the afterdepolarization reached action potential threshold causing prolonged self-sustained firing. These effects of metabotropic receptor activation were similar to the action of muscarinic agonists in the same preparation.