[The polyphosphoinisitide response evoked by different neuromediators after exposure to a helium-oxygen environment...

Male Wistar rats were subjected to normoxic helium-oxygen mixture under 40 kg/cm2 pressure with subsequent decompression. Their brain's Ach, dopamine, glutamate, substance P were shown to change the turnover rate of the synaptosomal PPI. The findings suggest an unspecific mechanism of action of high tension helium on the neurons. The data obtained shows the high pressure neural syndrome not to be connected with metabolic change of a single neurotransmitter.