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Related Experiment Videos

Spherical microparticles in human myocardium: an ultrastructural study.

V J Ferrans, K U Thiedemann, B J Maron

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |October 1, 1976
    PubMed
    Summary

    Spherical microparticles (SMP) were found in heart biopsies of patients with heart disease, associated with cell damage and fibrosis. These particles appear to play a role in remodeling cellular surfaces, particularly intercellular junctions.

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    Area of Science:

    • Cardiovascular Pathology
    • Cell Biology
    • Electron Microscopy

    Background:

    • Spherical microparticles (SMP) are observed in myocardial biopsies.
    • Their presence is linked to various heart conditions and cellular changes.

    Purpose of the Study:

    • To investigate the occurrence and characteristics of SMP in human myocardial tissue.
    • To understand the association of SMP with specific heart diseases and cellular pathology.

    Main Methods:

    • Analysis of myocardial biopsies from patients with diverse heart diseases.
    • Identification and characterization of SMP using electron microscopy.
    • Correlation of SMP presence with interstitial fibrosis and muscle cell degeneration.

    Main Results:

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    • SMP, averaging 500 A, were found in 29 of 70 patients across multiple heart conditions.
    • SMP were consistently associated with interstitial fibrosis and muscle cell degeneration.
    • Particles were located on cell surfaces, in intercellular spaces, and within cytoplasmic vesicles, often joined by nexuses.

    Conclusions:

    • SMP formation in the heart is linked to cellular surface remodeling, especially in dissociating intercellular junctions.
    • SMP are not exclusive to myocardium and may be a common cellular response.
    • The findings suggest a role for SMP in the pathological processes of heart disease.