Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Function and molecular structure of IL-12].

K Oshimi1, S Hoshino

  • 1Department of Hematology, Tokyo Women's Medical College.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interleukin-7 and its Effects on Leukemia and Lymphoma Cells.

Leukemia & lymphoma·2016
Same author

Colony Stimulating Activities of GM-CSF, G-CSF and IL-3 on Blast Progenitors from Acute Myeloblastic Leukemia.

Leukemia & lymphoma·2016
Same author

Extranodal natural killer/T-cell lymphoma from skin or soft tissue: suggestion of treatment from multinational retrospective analysis.

Annals of oncology : official journal of the European Society for Medical Oncology·2012
Same author

Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma.

International journal of laboratory hematology·2009
Same author

Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type.

Annals of oncology : official journal of the European Society for Medical Oncology·2009
Same author

Central nervous system is a sanctuary site for chronic myelogenous leukaemia treated with imatinib mesylate.

Internal medicine journal·2009
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Natural killer cell stimulatory factor (NKSF), also known as interleukin-12, is a cytokine that enhances immune cell activity. It boosts interferon-gamma production and cytotoxic functions in T and NK cells.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cytokine Research

Context:

  • Interleukin-12 (IL-12), also identified as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a novel cytokine.
  • This cytokine is a 70 kDa heterodimer comprising two covalently linked glycosylated chains (40 and 35 kDa).
  • Initially discovered in the supernatant of human EB virus-transformed B lymphoblastoid cell lines.

Purpose:

  • To characterize the biological functions of Natural Killer Cell Stimulatory Factor (NKSF).
  • To investigate the synergistic effects of NKSF with other immune-modulating agents.
  • To elucidate the role of NKSF in T and NK cell activation and function.

Summary:

  • NKSF induces interferon-gamma production in T and NK cells, synergizing with IL-2, mitogens, and other stimuli.

Related Experiment Videos

  • It exhibits comitogenic effects on resting T cells and direct mitogenic effects on activated T or NK cell blasts.
  • NKSF enhances NK cell cytotoxic activity and synergizes with IL-2 in generating lymphokine-activated killer (LAK) cells.

    • Impact:

    • NKSF plays a crucial role in modulating innate and adaptive immune responses.
    • Understanding NKSF's functions provides insights into immune cell activation and differentiation.
    • This cytokine has potential implications for immunotherapy and the development of novel treatments for immune-related disorders.