Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myeloablative regimens in peripheral stem cell transplantation.

J O Armitage1

  • 1Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-3332.

Leukemia
|November 1, 1992
PubMed
Summary

Research is needed to compare high-dose chemotherapy regimens for autologous peripheral stem cell transplantation. Optimizing preparatory regimens, including drug combinations and doses, may improve outcomes and safety.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral T-Cell Lymphoma-A Brief Review.

Leukemia & lymphoma·2016
Same author

Autologous and allogeneic hematopoietic stem cell transplantation in follicular lymphoma.

Expert opinion on biological therapy·2015
Same author

Factors affecting the development of atrial fibrillation and atrial flutter (AF/AFL) following autologous hematopoietic SCT (auto-HSCT).

Bone marrow transplantation·2012
Same author

Chromosomal abnormalities in malignant lymphoma and Hodgkin's disease.

Leukemia & lymphoma·2011
Same author

The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-Cell Lymphoma Project.

Annals of oncology : official journal of the European Society for Medical Oncology·2009
Same author

Stromal gene signatures in large-B-cell lymphomas.

The New England journal of medicine·2008

Area of Science:

  • Hematology
  • Oncology
  • Stem Cell Transplantation

Background:

  • Autologous peripheral stem cell transplantation (APSCT) relies on high-dose therapy (HDT) regimens.
  • The optimal preparatory regimens for APSCT are not well-defined, presenting a significant research gap.
  • Existing regimens like CBV (Cyclophosphamide, BCNU, Vincristine) are widely used but require further investigation.

Purpose of the Study:

  • To highlight the need for research into the comparative effectiveness of different preparatory regimens for APSCT.
  • To identify key areas for investigation, including dose optimization and drug selection within regimens.
  • To emphasize the importance of prospective, multi-institutional trials to clarify the role of TBI and novel agents.

Main Methods:

  • The abstract suggests the necessity of prospective, randomized, multi-institutional trials.
  • It implies comparative studies evaluating different drug combinations and dose levels.
  • Future research may incorporate hematopoietic growth factors to assess their impact on safety.

Main Results:

  • Current literature suggests a potential dose-response effect even at high doses of preparatory regimens.
  • The specific contributions of individual drugs (cyclophosphamide, melphalan, hydroxyurea) when added to regimens like CBV remain uncertain.
  • The role of Total Body Irradiation (TBI) in conditioning regimens requires further elucidation.

Conclusions:

  • Significant research opportunities exist in optimizing preparatory regimens for APSCT.
  • Prospective, randomized, multi-institutional trials are essential to determine the relative merits of different regimens.
  • The integration of hematopoietic growth factors may enhance the safety profile of future APSCT regimens.

Related Experiment Videos