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Updated: Aug 14, 2026

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
Is clearance of HIV-1 viraemia at seroconversion mediated by neutralising antibodies?
K Ariyoshi1, E Harwood, R Chiengsong-Popov
1Department of Genitourinary Medicine and Communicable Diseases, St Mary's Hospital Medical School, London, UK.
Abstract:
The mechanism of clearance of human immunodeficiency virus-1 (HIV-1) viraemia is not fully understood. In two patients with acute HIV-1 infection, initial high titres of free infectious virus in plasma declined rapidly to undetectable levels within 4-8 weeks, an event that was coincident with seroconversion. Neutralising antibodies directed against the first autologous isolates taken during the viraemic periods could not be detected in either patient around the time of disappearance of plasma virus. In the absence of functional neutralising antibody, it is unlikely that humoral factors are responsible for the suppression of primary viraemia in early HIV infection.
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