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Summary
This case report details a major Lioresal (baclofen) overdose in a Huntington's disease patient. The patient experienced coma and respiratory failure but fully recovered with intensive supportive care.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Lioresal (baclofen) is a gamma-aminobutyric acid (GABA) analog used for muscle spasms.
- Huntington's disease is a progressive neurodegenerative disorder.
Observation:
- A 29-year-old woman with Huntington's disease ingested 900-970 mg of Lioresal.
- She presented with deep coma, absent brain stem reflexes, and respiratory arrest.
- Pupils were fixed and unreactive for 48 hours; cardiovascular support was required.
Findings:
- The patient required 72 hours of intensive care.
- One seizure occurred during the recovery phase.
- Complete recovery was achieved without specific antidotes.
Implications:
- This is the first reported major Lioresal overdose.
- Supportive care is the primary treatment for baclofen overdose.
- Understanding baclofen toxicity is crucial for patient management.