Detecting gene conversion: primate visual pigment genes
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D J Balding1, R A Nichols, D M Hunt
1School of Mathematical Sciences, Queen Mary and Westfield College, University of London, U.K.
Proceedings. Biological Sciences
|September 22, 1992
Abstract:
The effects of gene conversion can be detected in the DNA sequences of multigene families. We develop a permutation test of the significance of patterns of sequence mismatches, and apply it to the sequences of the red- and green-sensitive visual pigment genes of human and the diana monkey. Whereas conventional tests of the rate of sequence divergence are equivocal, the permutation test convincingly excludes divergence in the absence of gene conversion (p = 10(-6)).