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The many faces of scleroderma.

J D Smiley1

  • 1Arthritis Consultation Center, Presbyterian Hospital of Dallas, Texas 75231.

The American Journal of the Medical Sciences
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

This review explores systemic sclerosis (SSc) and related conditions, linking blood vessel tone and anoxia to fibrosis. It covers diagnostic tools, organ involvement, and treatments for SSc and scleroderma-like diseases.

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Area of Science:

  • Rheumatology and Immunology
  • Vascular Biology
  • Fibrosis Research

Background:

  • Systemic sclerosis (SSc) involves fibrosis and vascular dysfunction.
  • Understanding the role of anoxia in connective tissue activation is crucial.
  • Scleroderma-like conditions share clinical features with SSc.

Observation:

  • New insights into blood vessel tone regulation are presented.
  • The impact of anoxia on connective tissue fibrosis is examined.
  • Various diagnostic modalities for internal organ involvement in SSc are compared.

Findings:

  • Diagnostic tools like HRCT and PFTs aid in quantitating organ involvement.
  • Treatment strategies for Raynaud's phenomenon and renal crisis are discussed.
  • Octreotide shows promise for improving gastrointestinal dysfunction.

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Implications:

  • Integrates clinical SSc with molecular mechanisms of fibrosis.
  • Provides a comprehensive overview of diagnostic and therapeutic approaches.
  • Discusses the etiology of idiopathic SSc and related syndromes, including environmental factors.