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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 17, 2010
Toremifene resistance in a rat mammary tumour model
J A Kellen1, E Georges, V Ling
1Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
Anticancer Research
|September 1, 1992
Abstract:
The effect of Toremifene on cell growth in vitro was tested on the R3230AC rat mammary adenocarcinoma as model. Toremifene differed from Tamoxifen in that it did not induce resistance; some cross-resistance was observed in Tamoxifen tolerant tumour cell lines. Toremifene does not influence P-glycoprotein expression in this model and at the levels studied.
