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Prolactin bioassay and hyperprolactinemia
C A Peabody1, P N Schultz, M D Warner
1Department of Psychiatry, University of Texas Medical School, Houston.
Journal of Endocrinological Investigation
|July 1, 1992
Abstract:
The Nb2 rat lymphoma bioassay (BA) for prolactin (PRL) was performed in 26 subjects with hyperprolactinemia, 17 of whom had radiologic evidence of a pituitary adenoma. All subjects were treated with the long acting dopamine agonist CV 205-502. The radioimmunoassay (RIA) PRL significantly decreased with treatment but the BA/RIA PRL remained essentially the same, indicating that the relative bioactivity was unaffected.