Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Negative symptoms and hypofrontality in chronic schizophrenia.

A Wolkin1, M Sanfilipo, A P Wolf

  • 1Department of Psychiatry, New York University Medical Center, New York 10010.

Archives of General Psychiatry
|December 1, 1992
PubMed
Summary

Frontal lobe dysfunction, specifically reduced prefrontal cortex metabolism (hypofrontality), is closely linked to negative symptoms in schizophrenia patients. This association was regionally specific and not explained by other factors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Positron emission tomography in the study of aging and senile dementia.

Neurobiology of aging·2013
Same author

Is there evidence of birth control in late Imperial China?

Population and development review·2008
Same author

Commentary on: "Differential effects of amphetamine and neuroleptics on negative vs. positive symptoms in schizophrenia." Psychopharmacology (1980) 72:17-19.

Psychopharmacology·2001
Same author

Gamma vinyl-GABA differentially modulates NMDA antagonist-induced increases in mesocortical versus mesolimbic DA transmission.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2001
Same author

Effects of smoking on acoustic startle and prepulse inhibition in humans.

Psychopharmacology·2001
Same author

The selective sigma(1) receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl)piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats.

European journal of pharmacology·2001

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Negative symptoms of schizophrenia are thought to stem from frontal lobe dysfunction.
  • Previous studies noted similarities between frontal lobe lesions and negative symptoms.
  • Direct evidence linking frontal lobe function to negative symptoms in schizophrenia is limited.

Purpose of the Study:

  • To investigate the relationship between prefrontal cortex glucose metabolism and negative symptoms in schizophrenia.
  • To determine if reduced prefrontal metabolism (hypofrontality) is associated with negative symptom severity.

Main Methods:

  • Positron emission tomography (PET) was used to measure relative glucose metabolism in the prefrontal cortex.
  • 20 patients with chronic schizophrenia, not on neuroleptic medication, underwent PET scanning.

Related Experiment Videos

  • The severity of negative symptoms was assessed and correlated with metabolic activity.

    • Main Results:

    • A significant association was found between negative symptoms and reduced prefrontal cortex metabolism (hypofrontality).
    • The strongest correlation was observed in the right dorsolateral prefrontal cortex.
    • This relationship remained significant and was not influenced by age, cerebral atrophy, or positive symptom severity.

    Conclusions:

    • Prefrontal hypometabolism is directly associated with negative symptoms in schizophrenia.
    • The findings support the frontal lobe dysfunction hypothesis for negative symptoms.
    • The right dorsolateral prefrontal cortex may be a key region involved in this association.