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Proline-specific aminopeptidases: potential role in bradykinin degradation
G Vanhoof1, I de Meester, D Hendriks
1Laboratory of Medical Biochemistry, University of Antwerp, Wilrijk, Belgium.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
The N-terminus of bradykinin is shown to be sequentially degraded by the human proline-specific aminopeptidases aminopeptidase P (EC 3.4.11.9) and dipeptidyl peptidase IV (EC 3.4.14.5). Additional evidence is provided for the hypothesis that these proline-specific aminopeptidases play an essential role in the degradation of peptides containing an N-terminal Xaa-Pro sequence.