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Morphine analgesia in normal and alloxanized mice
1Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Archives Internationales De Pharmacodynamie Et De Therapie
|July 1, 1992
Summary
Diabetic mice show a reduced pain relief response to morphine, possibly requiring higher doses. Insulin therapy can restore normal morphine analgesia in diabetic subjects.
Area of Science:
- Pharmacology
- Endocrinology
- Pain Management
Background:
- Diabetes mellitus is characterized by hyperglycemia.
- Morphine is a widely used analgesic.
- The interaction between diabetes and morphine analgesia is not fully understood.
Purpose of the Study:
- To investigate the analgesic effect of morphine in diabetic mice.
- To explore the role of hyperglycemia and insulin in morphine analgesia.
Main Methods:
- Alloxan-induced diabetes model in mice.
- Hot plate test for analgesic response.
- Administration of morphine, insulin, and naloxone.
- Measurement of plasma glucose levels.
Main Results:
- Diabetic mice exhibited higher baseline pain tolerance.
- Morphine analgesia was decreased in diabetic mice compared to normal mice.
- Insulin replacement therapy normalized morphine analgesia in diabetic mice.
- Naloxone antagonized morphine's analgesic and hyperglycemic effects, with a greater glucose-lowering effect in diabetics.
Conclusions:
- Hyperglycemia in diabetes may impair morphine analgesia.
- Insulin therapy can restore analgesic efficacy of morphine in diabetic mice.
- Higher morphine doses might be necessary for effective pain management in diabetic patients.