Related Experiment Video
Updated: Mar 8, 2026

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
Published on: July 18, 2025
Retroperitoneal polyarteritis nodosa presenting as ureteral obstruction.
1Department of Pathology, University of California, Sacramento.
Retroperitoneal polyarteritis nodosa (PAN) presenting as ureteral obstruction is a rare initial manifestation. This report details two unique cases of this uncommon presentation of PAN, highlighting its diagnostic challenge.
Area of Science:
- Nephrology
- Urology
- Vascular Inflammation
Background:
- Polyarteritis nodosa (PAN) is a systemic vasculitis that can affect any organ.
- Retroperitoneal involvement is uncommon, and ureteral obstruction is a rare initial symptom.
Observation:
- Two patients presented with retroperitoneal polyarteritis nodosa (PAN).
- Ureteral obstruction was the primary presenting sign in both cases.
Findings:
- This presentation of PAN is previously unreported in medical literature.
- The cases highlight the diagnostic difficulties in recognizing retroperitoneal PAN presenting with ureteral obstruction.
Implications:
- Early recognition of this rare PAN manifestation is crucial for timely treatment.
- Consideration of PAN in the differential diagnosis of unexplained ureteral obstruction is warranted.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Acute Kidney Injury II: Pathophysiology
Kidney Transplant II: Surgical Procedure
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Acute Pyelonephritis I: Introduction
Ureters

