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Related Experiment Videos

E rosette formation in B cell chronic lymphocytic leukemia.

C Musolino1, E Di Cesare, A Alonci

  • 1Institute of Internal Medicine, Messina University, Italy.

Acta Haematologica
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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B cell chronic lymphocytic leukemia (CLL) lymphocytes gained the ability to form rosettes with sheep red blood cells during disease progression. This change was linked to the E rosette receptor, identified by the OKT11 antibody.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • B cell chronic lymphocytic leukemia (CLL) is a lymphoid malignancy characterized by the accumulation of malignant B lymphocytes.
  • Prolymphocytoid transformation represents an aggressive phase of CLL, often associated with altered cell surface markers and clinical behavior.

Observation:

  • A patient with CLL exhibited B lymphocytes capable of forming rosettes with sheep red blood cells (SRBCs).
  • This rosette formation occurred specifically during the prolymphocytoid transformation phase of the disease.
  • The leukemic B cells were recognized by the OKT11 monoclonal antibody, indicating the presence of the E rosette receptor.

Findings:

  • The capacity for sheep red blood cell rosette formation in CLL lymphocytes is associated with the expression of the E rosette receptor.

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  • This phenomenon was not observed at the initial diagnosis of CLL but emerged during disease progression.
  • The OKT11 monoclonal antibody confirmed the presence of the classic E rosette receptor on the transformed leukemic cells.

    • Implications:

    • The E rosette receptor expression on CLL cells during prolymphocytoid transformation may serve as a diagnostic or prognostic marker.
    • Understanding this phenomenon could offer insights into the immunobiology of CLL and its transformation.
    • Further evaluation of E rosette receptor expression in CLL could reveal novel therapeutic targets or diagnostic strategies.