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Measures of tumor proliferative activity
1Section of Hematology-Oncology, University of Arizona Cancer Center, Tucson 85713.
International Journal of Clinical & Laboratory Research
|January 1, 1992
Summary
Measuring tumor proliferative activity, or labeling index, offers insights into tumor biology and patient management. Newer monoclonal antibody techniques like Ki-67 are simple, available, and show prognostic value.
Area of Science:
- Oncology
- Pathology
- Biotechnology
Background:
- Tumor proliferative activity, or labeling index, is crucial for understanding human neoplasm biology.
- Assessing proliferative activity provides clinical information for patient management.
- Various standard and newer techniques exist for measuring tumor proliferative activity.
Purpose of the Study:
- To review methods for measuring tumor proliferative activity.
- To emphasize technical issues associated with these methods.
- To highlight the development and application of monoclonal antibodies Ki-67 and anti-PCNA/cyclin.
Main Methods:
- Review of literature on techniques for measuring tumor proliferative activity.
- Focus on monoclonal antibodies, specifically Ki-67 and anti-PCNA/cyclin.
- Evaluation of technical aspects and availability of these antibodies.
Main Results:
- Monoclonal antibodies Ki-67 and anti-PCNA/cyclin are readily available and simple to use.
- Ki-67 has demonstrated prognostic value in non-Hodgkin's large cell lymphomas.
- Studies suggest these techniques are useful for various carcinomas, soft tissue tumors, and CNS tumors.
Conclusions:
- Labeling index measurements provide valuable biological and clinical insights.
- Monoclonal antibody techniques offer a practical approach to assessing tumor proliferation.
- These methods hold potential for guiding patient management across diverse tumor types.