Related Experiment Videos
1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among
Insights
The CDC updated HIV classification, prioritizing CD4+ T-lymphocyte counts for clinical conditions. The AIDS surveillance case definition now includes lower CD4+ counts and additional conditions for public health reporting.
Area of Science:
- Immunology
- Public Health
- Infectious Diseases
Background:
- The 1986 CDC classification system for HIV infection required revision.
- CD4+ T-lymphocyte counts are crucial for assessing HIV-related clinical conditions.
Purpose of the Study:
- To revise the HIV infection classification system.
- To expand the AIDS surveillance case definition for public health practice.
Main Methods:
- Revised classification system emphasizing CD4+ T-lymphocyte counts.
- Expanded AIDS surveillance case definition including CD4+ counts < 200/microL or < 14%.
- Incorporated pulmonary tuberculosis, recurrent pneumonia, and invasive cervical cancer.
Main Results:
- New classification system highlights clinical importance of CD4+ T-lymphocyte counts.
- AIDS surveillance case definition expanded to include additional criteria and conditions.
- Revised system effective for AIDS case reporting starting January 1, 1993.
Conclusions:
- The revised classification system and expanded AIDS definition improve public health surveillance for HIV infection.
- Emphasis on CD4+ T-lymphocyte counts provides a clearer clinical categorization of HIV disease.
- Updated guidelines facilitate consistent and comprehensive AIDS case reporting nationwide.
Abstract:
CDC has revised the classification system for HIV infection to emphasize the clinical importance of the CD4+ T-lymphocyte count in the categorization of HIV-related clinical conditions. This classification system replaces the system published by CDC in 1986 (1) and is primarily intended for use in public health practice. Consistent with the 1993 revised classification system, CDC has also expanded the AIDS surveillance case definition to include all HIV-infected persons who have < 200 CD4+ T-lymphocytes/microL, or a CD4+ T-lymphocyte percentage of total lymphocytes of < 14. This expansion includes the addition of three clinical conditions--pulmonary tuberculosis, recurrent pneumonia, and invasive cervical cancer--and retains the 23 clinical conditions in the AIDS surveillance case definition published in 1987 (2); it is to be used by all states for AIDS case reporting effective January 1, 1993.