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Calcium channel blocking agents and potassium-stimulated release of glutamate from cerebellar slices
1Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Heath Park, Cardiff, UK.
European Journal of Pharmacology
|December 8, 1992
Abstract:
The effects of calcium channel blockers and tetrodotoxin on the potassium-stimulated release of endogenous glutamate from rat cerebellar slices was assessed. Verapamil (10 microM), omega-conotoxin (1 and 10 microM) and cobalt (2 mM) all significantly decreased release. Amiloride (100 microM) and tetrodotoxin (0.5 and 1 microM) had no effect. The results suggest a role for N-type voltage-operated calcium channels in the potassium-stimulated release of glutamate.