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Related Experiment Videos

Plasma androgen levels during the menstrual cycle.

A Vermeulen, L Verdonck

    American Journal of Obstetrics and Gynecology
    |June 15, 1976
    PubMed
    Summary

    This study found that testosterone (T), dihydrotestosterone (DHT), and delta 4 levels fluctuate significantly during the menstrual cycle in women. These androgen variations peak around ovulation and are lowest during the early follicular and late luteal phases.

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    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Gynecology

    Background:

    • Hormonal fluctuations are central to the ovulatory cycle.
    • Understanding androgen dynamics is crucial for reproductive health.

    Purpose of the Study:

    • To investigate the daily variations of key androgens during the normal ovulatory cycle.
    • To compare the cyclical patterns of testosterone, dihydrotestosterone, delta 4, and DHEA.

    Main Methods:

    • Radioimmunoassay (RIA) methods were employed.
    • Hormone levels were measured daily throughout the complete menstrual cycle in 15 women.
    • Included assessment of testosterone (T), dihydrotestosterone (DHT), delta 4, and dehydroepiandrosterone (DHEA).

    Main Results:

    • Significant cyclical variations were observed for T, DHT, and delta 4.
    • These androgens peaked during the periovulatory period.
    • Lowest levels of T, DHT, and delta 4 were found in the early follicular and late luteal phases.
    • DHEA levels exhibited random variations, lacking a discernible cyclical pattern.

    Conclusions:

    • Androgen levels, specifically T, DHT, and delta 4, exhibit distinct cyclical patterns throughout the ovulatory cycle.
    • DHEA levels do not follow a predictable cyclical variation.
    • Observed variations in androgen levels are statistically significant, though interindividual variability may obscure these findings in some studies.

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