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Effects of gadolinium on N-methyl-D-aspartate (NMDA)-induced centrogenic arrhythmias
L Berrino1, V De Novellis, S Maione
1Institute of Pharmacology and Toxicology, First Faculty of Medicine and Surgery, University of Naples, Italy.
Research Communications in Chemical Pathology and Pharmacology
|November 1, 1992
Abstract:
In urethane-anesthetized rats, the intracerebroventricular (i.c.v.) administration of N-methyl-D-aspartate (NMDA)-induced central arrhythmias. These cardiac rhythm disorders could be prevented by the i.c.v. microinjection of gadolinium, an inhibitor of exocytosis. These findings suggest that inhibition of central neurotransmitter exocytosis could protect against centrogenic arrhythmias.