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One-minute dithranol therapy in psoriasis: a placebo-controlled paired comparative study
1University of Göteborg, Department of Dermatology, Sahlgrenska Hospital, Sweden.
Acta Dermato-Venereologica
|November 1, 1992
Summary
Dithranol 2% ointment significantly improved chronic plaque psoriasis vulgaris compared to placebo. Most patients experienced clearing or improvement with dithranol, demonstrating its efficacy in treating this skin condition.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Psoriasis vulgaris is a chronic inflammatory skin disease.
- Plaque-type psoriasis is the most common form.
- Effective treatments are needed to manage psoriasis symptoms.
Purpose of the Study:
- To evaluate the efficacy and safety of dithranol 2% ointment in treating chronic plaque-type psoriasis vulgaris.
- To compare dithranol treatment with a placebo in a randomized controlled trial.
Main Methods:
- A double-blind, left-right randomized comparison was conducted.
- 27 patients with chronic plaque psoriasis vulgaris were treated.
- Dithranol 2% ointment and placebo were applied once daily for 8 weeks.
Main Results:
- 17 out of 27 patients showed clearing or considerable improvement with dithranol, versus 6 with placebo (p=0.002).
- Dithranol showed statistically significant improvement in erythema, infiltration, scaling, and overall results.
- No significant difference was observed for pruritus; no medical side effects were reported.
Conclusions:
- Dithranol 2% ointment is an effective treatment for chronic plaque-type psoriasis vulgaris.
- The study supports the use of dithranol for psoriasis management.
- Dithranol demonstrated a favorable efficacy profile with minimal side effects.