Statistical geometry of pancreatic islets

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In situ Quantification of Pancreatic Beta-cell Mass in Mice
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In situ Quantification of Pancreatic Beta-cell Mass in Mice

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H M Hastings1, B S Schneider, M A Schreiber

  • 1Department of Mathematics, Hofstra University, Hempstead, New York 11550.

Proceedings. Biological Sciences
|December 22, 1992
PubMed

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Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...