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Quality assurance and standards in hematopoietic progenitor processing.

S T Bennett1, N L Johnson, L C Lasky

  • 1Department of Pathology, LDS Hospital, Salt Lake City, Utah.

Journal of Clinical Apheresis
|January 1, 1992
PubMed
Summary

Quality assurance is crucial for hematopoietic progenitor cell processing, storage, and handling in bone marrow transplantation. Adhering to established standards and good laboratory practices ensures consistent, high-quality therapeutic procedures.

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Area of Science:

  • Hematology
  • Transplantation Medicine
  • Laboratory Science

Background:

  • Bone marrow transplantation is a vital therapeutic intervention.
  • Increased laboratory involvement in hematopoietic progenitor cell processing necessitates standardized protocols.
  • Quality assurance (QA) is essential for monitoring and ensuring compliance with laboratory standards.

Purpose of the Study:

  • To present concepts of quality assurance in hematopoietic progenitor cell processing.
  • To emphasize the importance of adhering to established standards and good laboratory practices.
  • To guide quality assurance programs in the absence of comprehensive published standards.

Main Methods:

  • Review of existing professional organization standards for hematopoietic progenitor processing.

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  • Application of principles of good laboratory practice.
  • Conceptual framework for quality assurance in cell processing.

    • Main Results:

    • Some standards for hematopoietic progenitor processing have been issued.
    • Current standards are not fully comprehensive but should be met or exceeded.
    • Good laboratory practice principles should guide QA in the absence of published standards.

    Conclusions:

    • Implementing robust quality assurance is critical for reliable hematopoietic progenitor cell processing.
    • Adherence to or exceeding published standards is recommended.
    • Good laboratory practices serve as a foundation for quality assurance programs.