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Mapping quantitative trait loci for behavioral traits in the mouse.

T E Johnson1, J C DeFries, P D Markel

  • 1Institute for Behavioral Genetics, University of Colorado, Boulder 80309.

Behavior Genetics
|November 1, 1992
PubMed
Summary

Understanding mouse behavior genetics requires identifying genes underlying quantitative trait loci (QTLs). This study proposes a multistage strategy for mapping QTLs to pinpoint specific genes influencing behavioral traits, aiding in genetic cause elucidation.

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Area of Science:

  • Behavioral genetics
  • Genomics
  • Mouse models

Background:

  • Most mouse behavioral traits are heritable, influenced by multiple genes or quantitative trait loci (QTLs).
  • Elucidating the mechanism of action of these QTLs is crucial for understanding individual behavioral differences.
  • Positional cloning, requiring precise genetic mapping, is a key strategy for identifying and cloning genes responsible for QTLs.

Purpose of the Study:

  • To propose a multistage strategy for quantitative trait loci (QTL) mapping in mice.
  • To facilitate the molecular identification of genes underlying behavioral traits.
  • To provide a framework for understanding the genetic basis of individual behavioral differences.

Main Methods:

  • Utilizing recombinant-inbred (RI) strains of mice for QTL mapping.

Related Experiment Videos

  • Characterizing genomic DNA from parental strains and RI strains for DNA markers.
  • Assessing quantitative traits in F2 mice derived from parental crosses and genotyping extreme F2 individuals.

    • Main Results:

    • The proposed strategy integrates data from RI strains and F2 crosses to refine QTL mapping.
    • It enables hypothesis testing for QTL localization based on RI strain analysis.
    • The approach facilitates molecular identification of candidate genes using the mouse genome database.

    Conclusions:

    • The outlined multistage strategy offers a robust method for QTL mapping in mice.
    • This approach aids in the molecular identification of genes influencing complex behavioral traits.
    • The strategy is exemplified by mapping QTLs related to neural sensitivity to ethanol anesthesia.