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Intracellular glutathione and its metabolizing enzyme activities in a metastatic variant melanoma cell line

A K Chakraborty1, M Ueda, Y Mishima

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510.

Melanoma Research
|December 1, 1992
PubMed

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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
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