(-)Deprenyl (selegiline) is devoid of amphetamine-like behavioural effects in rats

Central effects of high dose (-)deprenyl (50-100 mg/kg sc) was compared to that of (+)deprenyl and (+/-)amphetamine (AM). (+)Deprenyl and AM induced stereotyped behaviour, increased spontaneous motility in smaller and decreased it in higher doses, inhibited escape behaviour and shuttle-box avoidance. (-)Deprenyl failed to possess any of these effects, providing further evidence that AM-type metabolites have no share in the action of (-)deprenyl.