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Cross reactivity among the ligands of the 7 helix family
G Simon1, Z Pásztélyi, T Zelles
1Semmelweis Medical University, Department of Oral Biology, Budapest, Hungary.
Acta Physiologica Hungarica
|January 1, 1992
Abstract:
"Specific" drugs for receptors of the 7 helix family inhibited in high doses other receptors of the same family, as well. Atropine inhibited [3-H]-clonidine binding, beta-adrenergic drugs: propranolol, betoxalol, ICI 118.551 inhibited labelled QNB binding to all the 3 main subtypes of muscarinic receptors. Authors propose the existence of common features in the ligand binding sites of the receptors of 7 helix family.