[Torsades de pointes during sultopride poisoning]
Journal De Toxicologie Clinique Et Experimentale
|December 1, 1992
Summary
This case study details sultopride poisoning from a 16g overdose, presenting with severe symptoms including cardiac arrest. Prompt treatment with potassium chloride and pacemaker stimulation was crucial for managing life-threatening arrhythmias.
Area of Science:
- Pharmacology
- Toxicology
- Cardiology
Background:
- Sultopride is a substituted benzamide antipsychotic with known cardiac risks.
- Overdoses can lead to significant toxicity, necessitating prompt medical intervention.
Observation:
- A 35-year-old male presented with myoclonus, mydriasis, vomiting, and cardio-respiratory arrest after ingesting 16g of sultopride.
- Initial assessment revealed severe poisoning with high plasma (25 mg/l) and urinary (12 g/l) sultopride concentrations.
Findings:
- The patient developed Torsades de pointes, a polymorphic ventricular tachycardia.
- Treatment involved potassium chloride infusion and pacemaker stimulation to manage the cardiac arrhythmia.
Implications:
- Prolongation of the Q-T interval is a critical indicator of potential severe arrhythmias in sultopride poisoning.
- This case highlights the importance of cardiac monitoring and aggressive management in sultopride overdose scenarios.
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