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[Effect of denopamine on residual left ventricular dysfunction after complete revascularization]
H Kitazume1, Y Ageishi, T Iwama
1Department of Medicine, Bokuto Hospital, Tokyo.
Journal of Cardiology
|January 1, 1992
Summary
Denopamine treatment improved cardiac function in patients with residual left ventricular dysfunction post-angioplasty. The drug reduced left ventricular dimensions while preserving contractility, indicating enhanced cardiac performance.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Investigating treatments for residual left ventricular dysfunction post-percutaneous transluminal coronary angioplasty (PTCA).
- Assessing the efficacy of denopamine in patients with compromised cardiac function.
Purpose:
- To evaluate the effect of denopamine on left ventricular dimensions and function.
- To determine if denopamine improves cardiac performance in patients with post-PTCA left ventricular dysfunction.
Summary:
- Denopamine (15 mg/day) was given to 20 patients with residual left ventricular dysfunction.
- Echocardiography showed significant decreases in end-diastolic (58 to 54 mm) and end-systolic (44 to 40 mm) dimensions.
- % fractional shortening remained stable (25% to 27%), indicating preserved contractility.
Impact:
- Denopamine effectively improved left ventricular function by reducing chamber size.
- The drug demonstrated potential in managing cardiac dysfunction following coronary angioplasty.