Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Factors controlling pancreatic islet neogenesis.

A Vinik¹, G Pittenger, R Rafaeloff

¹Diabetes Research Institute, Eastern Virginia Medical School, Norfolk 23510.

The Yale Journal of Biology and Medicine

|September 1, 1992

Summary

A novel hamster model using cellophane wrapping can reverse diabetes by stimulating beta-cell regeneration from ductal tissue. This finding offers new avenues for diabetes mellitus treatment and islet cell research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

SUMMARY: GLIDING THROUGH THE GOLDEN YEARS GRACEFULLY.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2017

Same author

Sunitinib in pancreatic neuroendocrine tumors: updated progression-free survival and final overall survival from a phase III randomized study.

Annals of oncology : official journal of the European Society for Medical Oncology·2016

Same author

Mortality among African American women with sarcoidosis: data from the Black Women's Health Study.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2013

Same author

The etiology of uterine sarcomas: a pooled analysis of the epidemiology of endometrial cancer consortium.

British journal of cancer·2013

Same author

Fine-mapping in African-American women confirms the importance of the 10p12 locus to sarcoidosis.

Genes and immunity·2012

Same author

First steps in designing a videophone for people with dementia: identification of users' potentials and the requirements of communication technology.

Disability and rehabilitation. Assistive technology·2012

Area of Science:

Endocrinology
Regenerative Medicine
Diabetes Research

Background:

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia.
Beta-cell dysfunction and loss are central to diabetes pathogenesis.
Current treatments for diabetes have limitations and aim to manage, not cure, the disease.

Purpose of the Study:

To establish a preclinical model for inducing beta-cell regeneration.
To investigate the potential for reversing chemically induced diabetes.
To explore novel therapeutic strategies for diabetes mellitus.

Main Methods:

Induction of diabetes using streptozotocin in hamsters.
Application of cellophane wrapping to pancreatic tissue to induce regeneration.

Related Experiment Videos

Assessment of insulin secretion and glycemic control.

Main Results:

Cellophane wrapping induced beta-cell differentiation from ductal tissue, restoring normal insulin secretion.
The model demonstrated a "cure" rate of at least 50% for streptozotocin-induced diabetes.
Evidence suggests activation of pancreatic growth factors driving ductal cell proliferation and beta-cell differentiation.

Conclusions:

A novel model for beta-cell regeneration has been successfully established.
This model shows promise for developing new treatments for diabetes mellitus.
Further research into identified growth factors could lead to in vitro islet generation and improved transplant viability.