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Genetic aspects of multidrug resistance
1Laboratoire de recherche sur le cancer et les maladies du sang, Grand-Duchy of Luxembourg.
Medical Oncology and Tumor Pharmacotherapy
|January 1, 1992
Abstract:
Gene amplification is responsible both for dihydrofolate reductase induced methotrexate resistance, and for the P-glycoprotein encoding multigene family induced multidrug resistance. The 6 pairs of hydrophobic regions of the P-glycoprotein fold up in a snake-like structure through the lipidic layers of the cell membrane. Other detoxification mechanisms include the glutathione S-transferase 'pi', but without gene amplification.