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Related Experiment Videos

[Quality tests for ibuprofen preparations].

T Miyazaki, C Yomota, S Okada

    Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences
    |January 1, 1992
    PubMed
    Summary

    Quality testing of ibuprofen preparations revealed acceptable drug content and disintegration. However, some ibuprofen tablets failed dissolution tests, indicating potential bioavailability issues.

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    Area of Science:

    • Pharmaceutical Sciences
    • Drug Quality Control

    Context:

    • Assessing the quality of commercial ibuprofen preparations is crucial for ensuring therapeutic efficacy and patient safety.
    • Physical quality assessment methods, including drug content, disintegration, and dissolution testing, are standard pharmacopeial procedures.

    Purpose:

    • To evaluate the quality of 48 commercial ibuprofen preparations using physical testing methods.
    • To determine drug content, disintegration time, and dissolution profiles of selected ibuprofen tablets.

    Summary:

    • Spectrophotometry confirmed ibuprofen content within the 90-110% range for all preparations.
    • While most tablets met disintegration standards (Japanese Pharmacopoeia), 9 out of 36 failed dissolution testing (USP monograph), with less than 70% dissolved in 30 minutes.
    • These findings highlight variability in ibuprofen tablet dissolution, potentially impacting in vivo performance.

    Impact:

    • Identifies specific ibuprofen preparations that may require reformulation or closer monitoring to meet dissolution specifications.
    • Underscores the importance of robust dissolution testing in pharmaceutical quality control to predict drug performance.
    • Provides data for regulatory bodies and manufacturers to ensure consistent quality and efficacy of ibuprofen products.

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