[A clinical observation of vinyl chloride-induced disease]

Analysis is performed on the observed clinical picture of vinyl-chloride disease in 12 persons, developed at concentrations of toxic substance about MAC after exposure from 5 to 34 years. After enlarged clinical test on individual organs and systems the authors establish that the most frequent result of chronic poisoning with vinyl-chloride is the combination of peripheral neurovegetative symptoms with toxic hepatitis on the background of neurosis-similar (astheno-vegetative) manifestations. In the cases, observed by the authors, the poisoning takes a light course affecting the neurovegetative structures and prevailing of the vegetovasal forms of polyneuropathy ending with Raynaud-similar syndrome, or affecting the distal parts of the peripheral nerves with early electromyographic find. The Raynaud-similar syndrome and the bone changes ad specificity to the clinical picture, but are not constant manifestation of poisoning and can be developed at more continuous occupational exposure. The authors propose a discussion on the legality of the appelation vinyl-chloride disease in the cases, when not all classical clinic symptoms are present.