[Toxicokinetic and toxicodynamic indices in persons exposed to lead and manganese]

Subject to examination are 161 workers (118 men and 43 women) in professional contact with manganese and lead of the agglomeration production of Kremikovtsi. A complex of toxicokinetic (content of manganese in blood, urine and hair) and toxicodynamic indices is applied. Increased levels of manganese are established in the examined biological media. No plumbemia above 2.88 mumol/l is registered. The excretion of 5-amino-levulinic acid in urine is increased at a low rate. There are no considerable deviations in the clinic and chemical indices.