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[Toxic lesions in workers in the pharmaceutical industry]
Problemi Na Khigienata
|January 1, 1992
Summary
Workers exposed to aniline, phenylhydrazine, and organic solvents showed liver and kidney dysfunction, anemia, and neurological symptoms. Early detection and management are crucial for mitigating toxic effects in chemical plant workers.
Area of Science:
- Occupational Health
- Toxicology
- Clinical Medicine
Background:
- Chemical and pharmaceutical plant workers face occupational hazards.
- Exposure to aniline, phenylhydrazine, and organic solvents can lead to significant health issues.
Purpose of the Study:
- To evaluate the clinical and laboratory findings in workers with acute and chronic exposure to specific chemical agents.
- To assess the impact on liver, kidney, blood, and nervous systems.
Main Methods:
- Clinical examinations and comprehensive laboratory tests were conducted on 15 chemical plant workers.
- Tests included liver and kidney function, blood morphology, osmotic resistance of erythrocytes, and various biochemical markers.
Main Results:
- Moderately increased transaminase activity was observed in two-thirds of the workers.
- Four workers presented with significant anemia and lung syndrome.
- Diagnoses included chronic solvent exposure, aniline poisoning, and toxic hepatitis.
Conclusions:
- Combined exposure to organic solvents and specific chemicals like aniline poses significant health risks.
- Clinical syndromes associated with occupational chemical exposure require thorough investigation and management.