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Positive control of gene expression in procaryotes.

R E Drew1

  • 1Department of Biochemistry and Molecular Biology, University College London, England.

Science Progress
|January 1, 1992
PubMed
Summary

Gene expression in prokaryotes is regulated by complex control networks. Positive control mechanisms ensure fail-safe gene regulation, preventing unintended constitutive expression.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Genetics

Background:

  • Prokaryotic gene expression involves intricate regulatory networks.
  • Understanding these networks is crucial for deciphering cellular processes.

Purpose of the Study:

  • To elucidate the mechanisms of positive control in prokaryotic gene expression.
  • To analyze the interplay between positive and negative regulatory systems.

Main Methods:

  • Review of existing literature on prokaryotic gene regulation.
  • Analysis of transcription control mechanisms including RNA polymerases, sigma factors, activator proteins, and antitermination systems.

Main Results:

  • Prokaryotes utilize global, operon-specific, and temporal control networks.
  • Positive control mechanisms involve transcription apparatus components, activator proteins, and antitermination systems.
  • Negative control systems often modulate the activity of positive regulators.

Conclusions:

  • Gene expression regulation in prokaryotes rarely relies on simple positive control alone.
  • Positive control circuits provide robust, fail-safe regulation, minimizing constitutive gene expression upon mutation.

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