Influence of Metizol ("polfa") on the liver of pregnant rats

Drugs are the largest group of substances inactivated by the liver. They may have a stimulatory or inhibitory effect on the system of hepatic enzymes. Metizol is a thyrostatic belonging to the group of trimidazole derivatives. Its mechanism of action consists in inhibition of triiodothyronine++ and thyroxin secretion by the thyroid, owing to inactivation of the enzymes causing iodination of the thyrosine groups of thyroglobulin. This relatively little toxic drug when used for a prolonged period may lead to hyperaemia of the thyroid, and in pregnant women (by passing through the placenta) its side effects may threaten the foetus. The future mother affected with hyperthyroidism should receive full Metizol doses to avoid the danger of a thyroid crisis. A radical improvement of her health should be reached before childbirth.