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Graft engineering: the evolution of hematopoietic transplantation
1Graft Engineering Laboratory, Johns Hopkins Oncology Center, Baltimore, MD 21205.
Journal of Hematotherapy
|January 1, 1992
Abstract:
In vivo therapeutic manipulation as well as ex vivo grafting are important strategies for bone marrow manipulation and transplantation. This review article discusses the early techniques for marrow processing and manipulation as a background for discussing later graft engineering protocols, as well as preclinical and experimental protocols designed to modify transplantation biology at the multidisciplinary level. The direction of future trials in graft transplantation is also discussed.